Research Paper Volume 12, Issue 7 pp 6401—6414

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

Figure 4. The effect of spermidine and spermine on neurodegeneration in SAMP8. (A) Western blot of NGF, PSD93, PSD95 and BDNF. (B) The expression of BDNF in the brain. (C) The expression of NGF in the brain. (D) The expression of PSD93 in the brain. (E) The expression of PSD95 in the brain. (Data represent mean ± SEM (n = 3 per group). #P < 0.05, ##P < 0.01, ###P < 0.001 vs. SAMR1; *P < 0.05, **P < 0.01, ***P < 0.001 vs. SAMP8.