Research Paper Volume 12, Issue 7 pp 6401—6414

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

Figure 5. Spermidine and spermine redress mitochondrial dysfunction in SAMP8. (A) The western blot of mitochondrial protein. (B) The expression of MFN1 in the brain. (C) The expression of MFN2 in the brain. (D) The expression of P-DRP1 in the brain. (E) The expression of COX IV in the brain. (F) The concentration of ATP in the brain. Data represent mean ± SEM (n = 3 per group). #P < 0.05, ##P < 0.01, ###P < 0.001 vs. SAMR1; *P < 0.05, **P < 0.01, ***P < 0.001 vs. SAMP8.