Research Paper Volume 12, Issue 7 pp 6401—6414

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

Figure 7. Spermidine and spermine depress apoptosis in SAMP8. (A) The western blot of apoptotic protein. (B) The expression of Bax and Bcl-2 in the brain. (C) The expression of Caspase-3 in the brain. (D) TUNEL staining in cortex. Scale bar: 50μm. Data represent mean ± SEM (n = 3 per group). #P < 0.05, ##P < 0.01, ###P < 0.001 vs. SAMR1; *P < 0.05, **P < 0.01, ***P < 0.001 vs. SAMP8.