Research Paper Volume 12, Issue 7 pp 6401—6414

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

Figure 8. Spermidine and spermine ameliorate inflammation in SAMP8. (A) The western blot of inflammatory protein. (B) The expression of NLRP3 in the brain. (C) The expression of IL-1β in the brain. (D) The expression of IL-18 in the brain. Data represent mean ± SEM (n = 3 per group). #P < 0.05, ##P < 0.01, ###P < 0.001 vs. SAMR1; *P < 0.05, **P < 0.01, ***P < 0.001 vs. SAMP8.