Figure 3. Modular analysis of protein-protein interaction network and functional enrichment analysis. (A) The modules and the module genes, the colors indicated the different modules. (B) Each module contains up-regulated and down-regulated genes. Blue indicates down-regulation of gene expression, while red indicates up-regulation of gene expression. (C) Biological process with more than 3 functional modules significantly enriched in. Blue indicates down-regulation of BPs, while red indicates up-regulation of BPs. (D) KEGG pathways which more than 2 functional modules enriched in. Blue indicates down-regulation of KEGG pathways, while red indicates up-regulation of KEGG pathways. (E) GSEA of KEGG pathway in USP22-KD H1975 cells compared to negative control. LogFC > 0 indicated that the pathway was activated, while logFC < 0 indicated that the pathway was suppressed. Blue indicated the activated pathway was with logFC > 0.4, while green indicated the suppressed pathway was with logFC < -0.4.