Research Paper Volume 12, Issue 8 pp 7015—7029

Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mice

Figure 8. Quercetin activates SIRT1 and relieves ER stress in db/db mice. Western blot analysis: (A) SIRT1; (B) P-PERK/PERK; (C) P-IRE1α/IRE1α; (D) ATF6; (E) BIP; (F) PDI; (G) P-eIF2α/eIF2α. Quercetin-L: 35mg/kg/d; Quercetin-H: 70mg/kg/d. Data represent mean ± SEM (n = 10 per group). #p < 0.05, ##p < 0.01, ###p < 0.001vs. db/m; * p < 0.05, ** p < 0.01, *** p < 0.001 vs. db/db.