Research Paper Volume 12, Issue 8 pp 7282—7298

HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27

Figure 7. HMGN5 interacts with Hsp27 to modulate tumor growth in a nude mouse model. The appearance (A), tumor volume (B), and tumor weight (C) of tumors derived from Hsp27 and/or HMGN5-overexpressing J82 cells. The appearance (D), tumor volume (E), and tumor weight (F) of tumors derived from Hsp27 and/or HMGN5 silenced J82 cells. (G) The protein levels of E-cadherin and Vimentin in tumors derived from Hsp27 and/or HMGN5 overexpressing J82 cells. (H) The protein levels of E-cadherin and Vimentin in tumors derived from Hsp27 and/or HMGN5 silenced J82 cells. The data are presented as the mean ± SD of three independent experiments. *P<0.05, **P<0.01, ##P<0.01.