Research Paper Volume 12, Issue 8 pp 7313—7333

Estrogen regulation of germline stem cell differentiation as a mechanism contributing to female reproductive aging

Figure 4. Stra8 is involved in E2-induced oogenesis in vivo. (A) Primordial follicle numbers in ovaries of young adult pStra8-HSVtk mice, pretreated with vehicle (V) or GCV (10 mg/kg) for 7 days, 24 hours after injection of E2 (0.5 m/kg) (mean ± SEM, n = 5–7 mice per group; *P<0.05). (B) Effects of vehicle (V) or E2 (0.5 mg/kg) injection on numbers of primordial follicles in ovaries of young adult pStra8-GFP mice pretreated without or with GCV (10 mg/kg) for 7 days (mean ± SEM, n = 5–7 mice per group; *P<0.05).