Research Paper Volume 12, Issue 12 pp 11364—11385

Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1α mitochondrial metabolic pathway

Figure 5. Differences in genes and pathways analyzed using bioinformatics in the Sirt1-high and Sirt1-low group of LY-10 cells. (A) High-throughput sequencing was used to detect differences in the transcriptional levels of LY-10 cells in the Sirt1-high and Sirt1-low groups. The cluster of differentially expressed genes between the Sirt1-high and Sirt1-low groups. (B) The volcano map of transcriptome sequencing results. (C) Enrichment plots of the KEGG pathway analysis with the highest score and lowest p value for the Enrichment score. (D) The PPAR signaling pathway was analyzed using GSEA assays in the Sirt1-high and Sirt1-low groups. (E) Cytokines associated with the PPAR signaling pathway in the Sirt1-high and Sirt1-low groups.