Research Paper Volume 12, Issue 13 pp 12799—12811

Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats

Figure 1. Identification of tomatidine-target genes and the common KEGG pathways of OA-related and tomatidine-target genes. (A) Interaction network of 22 tomatidine-target genes based on STITCH database analysis. (B) MAPK1, MAPK3, JUN, DUSP1, FOS, and TP53 have the highest weights in the interaction network constructed using Gephi. (C) KEGG pathway analyses shows 105 OA-related and 76 tomatidine-target gene-related KEGG pathways. Among these, 39 (27.5%) KEGG pathways are common to both OA and tomatidine-target genes. (D) Gene enrichment analyses show that MAPK1, MAP2K1, MAPK3, and RAF1 are involved in all the top five KEGG pathways. The top three genes with highest degree are MAPK1, MAPK3, and FOS. (E) The circular visualization shows chromosomal positions and connectivity of tomatidine-target genes. The names of the tomatidine-target genes are shown in the outer circle, which represents chromosomes. The lines from each gene represent specific chromosomal locations. colors show Different values of degree, betweenness and closeness are shown in different colors. The three hub genes are shown in red.