Research Paper Volume 12, Issue 13 pp 12799—12811

Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats

Figure 11. The anti-inflammatory mechanism of action of tomatidine in primary articular chondrocytes and the OA model rats. The schematic diagram shows that tomatidine suppresses IL-1β-induced expression of iNOS, COX-2, MMPs and ADAMTS-5, and degradation of aggrecan and collagen-II by inhibiting the NF-κB and MAPK pathways.