Research Paper Volume 12, Issue 12 pp 11446—11465

microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway

Figure 5. miR-9 and miR-29a aggravate the structural pathological changes of the sciatic nerves in rats with DM. (A) The sciatic nerves of normal rats and rats with DM following lentiviral infection detected by HE staining (× 200). (B) The sciatic nerve detection of normal rats and rats with DM following lentiviral infection examined by electron microscope (× 10000). (C) AR activity of sciatic nerve detection in normal rats and rats with DM following lentiviral infection; * p < 0.05 vs. the normal group; # p < 0.05 vs. the DM group; @ p < 0.05 vs. the LV-ISL1 + LV-miR-9 group; & p < 0.05 vs. the LV-ISL1 + LV-miR-29a group. Results were measurement data and expressed as mean ± standard deviation; one way analysis of variance was used to analyze data among multiple groups; n = 8; the experiment was repeated three times independently.