Research Paper Volume 12, Issue 11 pp 10359—10369

Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53

Figure 5. KEGG pathways related to resveratrol-targeted genes. (A) Resveratrol-targeted genes related to the Prostate cancer pathway. (1) The PI3K-Akt signaling pathway and (2) p53 signaling pathways are associated with impaired G1/G2 arrest, reduced apoptosis, and genomic instability. (B) Resveratrol-targeted genes related to pathways in cancer. (1) The PI3K-Akt signaling pathway is associated with apoptosis evasion and proliferation. (C) Resveratrol-targeted genes related to the glioma pathway. (2) The p53 signaling pathway and (3) cell cycle pathway are associated with G1/S progression, uncontrolled proliferation, increased survival, and genomic instability. (D) Resveratrol-targeted genes related to the p53 signaling pathway. (3) The cell cycle pathway is associated with cell cycle arrest and p53 negative feedback. (E) Resveratrol-targeted genes related to the cell cycle signaling pathway, which is associated with biosynthesis of S-phase proteins and CycE DNA.