Research Paper Volume 12, Issue 11 pp 10415—10426

CHK2 is essential for spindle assembly and DNA repair during the first cleavage of mouse embryos

Figure 2. Disruption of CHK2 activity inhibited cleavage during early embryonic development in mice. (A) Representative image showing the development of early embryos in the 25 μM treatment group and the control group at 24 h and 48 h. (B) The rate of 2-cell embryo formation in the 25 μM treatment group was significantly lower than that in the control group (32.5 ± 2.63%, n = 137, 25 μM vs. 85.5 ± 7.42%, n = 158, control, p < 0.05). (C) The rate of 4-cell embryo formation in the 25 μM treatment group was significantly lower than that in the control group (16.8 ± 2.22%, n = 236, 25 μM vs. 53.6 ± 7.44%, n = 260, control, p < 0.01). **significant difference (p < 0.01), *significant difference (p < 0.05).