Research Paper Advance Articles

Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2

Figure 3. Effect of CL on sleep deprivation induced anxiety-like behaviors. (A) Sample traces of locomotor activity in the open field test. (B) The total distance traveled and (C) time spent in the center area. (D) The total distance traveled (during the 15-minute test) was summarized. (E) Sample traces of locomotor activity in the elevated plus maze test. (F) The total arm entrances. (G) The entrance into the open arms and (H) time spent in the open arms. Data values were expressed as the mean ± SEM (n=12), ##P < 0.01 vs. control group; *P < 0.05 and **P < 0.01 vs. SD group.