Research Paper Advance Articles

Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2

Figure 7. The protective effects of EA on glutamate-induced toxicity in neuronal cells. (A) The expression levels of Nrf2 and TLR4 significantly decreased in the siRNA treatment group. (B) and (C) Effect of EA on ROS levels in Nrf2 or TLR4 siRNA-transfected and Glu-treated neuronal cells. (D) and (E) Effect of EA on cell viability in Nrf2 or TLR4 siRNA-transfected and Glu-treated neuronal cells. Data values were expressed as the mean ± SEM (n=3), ##P < 0.01 vs. control group; *P < 0.05 and **P < 0.01 vs. Glu group; &P < 0.05 and &&P < 0.01 vs. EA-treated Glu group.