Research Paper Volume 12, Issue 11 pp 10506—10516

Modification of graphene oxide by angiopep-2 enhances anti-glioma efficiency of the nanoscaled delivery system for doxorubicin

Figure 6. Angiopep-2 polypeptide-modified and doxorubicin-loaded graphene oxide (ANG-Dox-GO) exhibited better anti-tumor effect of glioma xenograft mice. (A) The tumor volumes of mice with different treatments, including PBS (control), Dox (2 mg/kg), Dox-GO (containing 2 mg/kg of Dox), and ANG-Dox-GO (containing 2 mg/kg of Dox), respectively, every two days for 20 days. (B) The tumor weights of mice with different treatments, including PBS (control), Dox (2 mg/kg), Dox-GO (containing 2 mg/kg of Dox), and ANG-Dox-GO (containing 2 mg/kg of Dox), respectively, on 20 days. *P < 0.05.