Research Paper Advance Articles

LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264

Figure 5. SOCS2-AS1 suppressed CRC progression through promoting SOCS2 expression. (A) Expression of SOCS2 in TCGA data through GEPIA tool (http://gepia.cancer-pku.cn/detail.php). (B) Expression of SOCS2 in TCGA data through UALCAN tool (http://ualcan.path.uab.edu/analysis.html). (C) qRT-PCR analysis of SOCS2 expression in CRC tissues and normal tissues. (D) IHC analysis for SOCS2 expression in CRC tissues and paired normal tissues. (E) Expression levels of SOCS2 were determined in CRC cell lines by qRT-PCR. (F, G) CCK8 and colony formation assays were utilized to estimate cell proliferation. (H, I) Transwell assay was conducted to test cell migration and invasion. *P<0.05.