Research Paper Volume 12, Issue 11 pp 10544—10555

Long noncoding RNA LINC00460 conduces to tumor growth and metastasis of hepatocellular carcinoma through miR-342-3p-dependent AGR2 up-regulation

Figure 4. Knockdown of LINC00460 suppresses AGR2 expression by targeting miR-342-3p. (A) Bioinformatics prediction showed the complementary sequence between AGR2 and miR-342-3p. (B) The targeting relationship between AGR2 and miR-342-3p was further verified by the luciferase reporter assay. (C) Relative expression of AGR2 was detected through qRT-PCR. (DF) The trend lines between the level of LINC00460, AGR2 and miR-342-3p. *P < 0.05, **P < 0.01vs the control group. #P < 0.05 vs the si- LINC00460 group.