Research Paper Volume 12, Issue 11 pp 10556—10577

T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice

Figure 1. Effect of T1-11 on cellular senescence after BeSO4- and D-gal-induced senescence. (A, C) Effect of pre-treatment of T1-11 on BeSO4- and D-gal-induced cellular senescence markers, SA-β-gal activity, in SH-SY5Y cells. (B, D) Effect of pre-treatment of T1-11 on BeSO4- and D-gal-induced cellular senescence related molecules in SH-SY5Y cells. Data are mean±SEM from at least five independent experiments. Significant difference between control and treated cells is indicated by **p < 0.01. Significant difference between the cells treated with D-gal or BeSO4 alone and the cells treated with D-gal or BeSO4 combined with T1-11 is indicated by #p < 0.05, ##p < 0.01.