Research Paper Volume 12, Issue 11 pp 10556—10577

T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice

Figure 4. T1-11 ameliorates behavior deficits in D-gal-induced aging mice. The tasks of burrowing (A) and nesting (B) were performed after treatment. Data are mean±SEM (n = 6). Significant difference between control and D-gal-induced aging mice is indicated by * p < 0.05, ** p < 0.01 compared with the control group. Significant difference between the mice treated with D-β-gal alone and the mice treated with D-gal combined with Vit.E or T1-11 is indicated by #p < 0.05, ##p < 0.01 compared with D-gal group. 1: Control; 2: D-gal (200 mg/kg); 3: D-gal (200 mg/kg) + Vit.E (100 mg/kg) (positive control); 4: D-gal (200 mg/kg) + T1-11 (1 mg/kg); 5: D-gal (200 mg/kg) + T1-11 (10 mg/kg).