Research Paper Volume 12, Issue 11 pp 10578—10593

CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression

Figure 6. CARM1 is upregulated in NSCLC patients and positively correlated with CCNE2 levels. (A) Representative images of IHC staining of CARM1 in 20 cases of NSCLC patients (Tumor) and their adjacent non-tumor tissues (Normal). (B) Representative images of IHC staining of CCNE2 in 20 cases of NSCLC patients (Tumor) and their adjacent non-tumor tissues (Normal). (C) H score of CARM1 expression in 20 cases of NSCLC tumor tissues and their adjacent non-tumor tissues. **P < 0.01. (D) H score of CCNE2 expression in 20 cases of NSCLC tumor tissues and their adjacent non-tumor tissues. **P < 0.01. (E) Pearson correlation analysis was performed to examine the correlation between CARM1 and CCNE2 expression in 20 cases of NSCLC patients (n = 20; r = 0.6958; P < 0.01). (F) Analysis of data from the Kaplan-Meier plotter database suggested that high expression of CARM1 (Cutoff value: 262) was associated with shorter 10-year overall survival of NSCLC (lung adenocarcinoma, n = 461) patients. P < 0.01. (G) Analysis of data from the Kaplan-Meier plotter database suggested that high expression of CCNE2 (Cutoff value: 228) was associated with shorter 10-year overall survival of NSCLC (adenocarcinoma) patients. P < 0.01.