Research Paper Volume 12, Issue 11 pp 10594—10613

Coagulation factor 2 thrombin receptor promotes malignancy in glioma under SOX2 regulation

Figure 3. F2R plays an important role in the metastasis and invasion of glioma cells. (A, B). Wound-healing assay showed that F2R knockdown suppressed U87 and U251 cells migration. Representative images (A) and average migration rate (B) are shown. (C, D). Transwell assay showed that F2R knockdown suppressed glioma cell invasion. Representative images (C) and average number of cells (D) are shown. (E, F) Wound-healing assay showed that F2R overexpression promoted U87 and U251 cells migration. Representative images (E) and average migration rate (F) are shown. (G, H). Transwell assays showed that F2R overexpression promoted glioma cell invasion. Representative images (G) and average number of cells (H) are shown. All experiments were repeated at least three times. Data are presented as the mean ± SEM. *P<0.05.