Figure 2. Hsa_circ_0085576 is related to the clinicopathological characteristics of ccRCC patients. (A) Fold changes of hsa_circ_0085576 in 40 paired ccRCC tissues. (B) High hsa_circ_0085576 expression was associated with advanced TNM stage, tumor size and lymph node metastasis. (C) Receiver operating characteristic (ROC) analysis was used to determine the cut-off value of hsa_circ_0085576 in 45 non-metastasis and 31 metastasis ccRCC patients. Cut-off value=4.447. (D) Association of hsa_circ_0085576 expression with OS analysis of 76 ccRCC patients. (E) Association of hsa_circ_0085576 expression with DFS analysis of 76 ccRCC patients.