Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Figure 14. Up-regulation of miR-137 or inhibition of Src suppresses apoptosis of neuron cells. (A) neuronal cell viability after treatment with miR-137 mimic or si-Src measured using CCK-8; (B) neuronal cell activity after treatment with miR-137 mimic or si-Src measured using MTS assay; (C) apoptosis rate of neuron cells treated with miR-137 mimic or si-Src measured using Annexin V-FITC/PI double staining. Measurement data are expressed as mean ± standard deviation. Data among multiple groups are compared using one-way ANOVA, followed by Tukey's post hoc test and those among multiple groups at different time points were compared using two-way ANOVA, followed by Bonferroni's post hoc test. * p < 0.05 vs. normal astrocytes; # p < 0.05 vs. OGD-induced astrocytes treated with negative controls; & p < 0.05 vs. astrocytes treated with miR-137 inhibitor. The experiment was repeated 3 times independently.