Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Figure 2. Inhibition of p38 or Erk2 ameliorates cerebral infarction and improves neuronal function, learning, and memory abilities in MCAO mice. (A) neurological function scores in mice in each group; (B) rate of left limb fault step of mice after treatment with si-p38, si-Erk2 or in combination; (C) latency period and number of errors of mice treated with si-p38, si-Erk2 or in combination; (D) changes in the volume of infarct in mice treated with si-p38, si-Erk2 or in combination using TTC staining; (E) changes in the number of neurons from mice treated with si-p38, si-Erk2 or in combination using Nissl staining (× 400). Measurement data are expressed as mean ± standard deviation and compared by one-way ANOVA, followed by Tukey's post hoc test; * p < 0.05 vs. control group (sham-operated wild-type mice); # p < 0.05 vs. MCAO group (wild-type mouse models of MCAO). N = 15.