Research Paper Volume 12, Issue 11 pp 10969—10982

P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6

Figure 8. Schematic of the anti-inflammatory mechanism of P22077. P22077 promotes K48-linked ubiquitination and degradation of TRAF6, and subsequently inhibits the LPS-induced NF-κB and MAPKs pathway to alleviate inflammation.