Research Paper Volume 12, Issue 11 pp 11100—11115

ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L

Figure 8. CDC5L expression is increased in multiple myeloma cell lines, which can be promoted by ANXA7. (A) The protein expression of CDC5L in MM cell lines was detected by Western blot analysis. *P<0.05 and ***P<0.001 vs. HS-5 group. (B) The protein expression of CDC5L in U266 and RPMI8226 cells after transfection of OE-ANXA7 was detected by Western blot analysis. *P<0.05 vs.U266 group. #P<0.05 vs. U266-OE-NC group. ΔΔΔP<0.001 vs. RPMI8226 group. $$$P<0.001 vs. RPMI8226- OE-ANXA7 group. (C) The protein expression of CDC5L in U266 and RPMI8226 cells after transfection of shRNA-ANXA7 was detected by Western blot analysis. **P<0.01 vs.U266 group. ##P<0.01 vs. U266-shRNA-NC group. ΔΔΔP<0.001 vs. RPMI8226 group. $$$P<0.001 vs. RPMI8226-shRNA-ANXA7 group.