Research Paper Volume 12, Issue 11 pp 11116—11138

Deoxyelephantopin induces apoptosis via oxidative stress and enhances gemcitabine sensitivity in vitro and in vivo through targeting the NF-κB signaling pathway in pancreatic cancer

Figure 5. Effect of DET on NF-κB activity in gemcitabine-resistant BxPC-3 cell line. (A) Effect of DET on NF-κB activity. Quantitative statistics of immunoblotting assays for IκB-α levels (B), p-IκB-α levels (C), NF-κB-p50 levels (D), NF-κB-p65 levels (E). *P < 0.05, **P < 0.01 versus CTL. CTL, control. (F) Effect of DET and IKK 16 on NF-κB activity. (G) Quantitative statistics of immunoblotting assays for NF-κB-p65 levels. **P < 0.01 versus CTL. CTL, control. (H) Effect of DET and IKK 16 on cell viability. *P < 0.05, **P < 0.01 versus CTL. ##P < 0.01 versus CTL added IKK 16. CTL, control.