Research Paper Volume 12, Issue 12 pp 11653—11666

Long non-coding RNA RP11-59H7.3 promotes cell proliferation and invasion metastasis in colorectal cancer by miR-139-5p/NOTCH1 axis

Figure 8. The lncRNA RP11-59H7.3 deregulation inhibits cell invasion and proliferation in CRC orthotopic xenografts. (AC) representative IVIS images showing size of tumors (A), macroscopic appearance (B), and metastasis (C) in sh-lncRNA RP11-59H7.3 groups vs control groups. (DF) Representative IVIS images showing tumor size (D), macroscopic appearance (E), and metastasis (F) in pcDNA-RP11-59H7.3 groups vs control groups. (GI) Representative macroscopic appearance and IVIS image of metastatic foci (white arrows) in the liver (G), lung (H), and spleen (I). **p < 0.01; *p < 0.05.