Research Paper Volume 12, Issue 12 pp 12074—12085

Agonism of GPR120 prevented IL-1β-induced reduction of extracellular matrix through SOX-9

Figure 4. Treatment with GW9508 prevented IL-1β-induced reduction of type II collagen and aggrecan in ATDC5 chondrocytes. Cells were treated with IL-1β (10 ng/ml) with or without GW9508 (50 μM) for 24 h. (A). mRNA of type II collagen and aggrecan; (B). Protein of type II collagen and aggrecan (^^^, ***, P<0.0001 vs. control group; ###, P<0.0001 vs. IL-1β treatment group, n=4-5).