Research Paper Volume 12, Issue 13 pp 13059—13075

Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway

Figure 1. Expression of AKR1B10 in CRC tissues. (A) Representative IHC images showing in situ AKR1B10 expression in CRC and normal tissues (scale bar = 100μm). (BE) IHC scores of AKR1B10 in (B) CRC vs normal tissues, (C) T I-II vs T III-IV tissues, (D) tumors with or without lymph node invasion, and (E) early vs late TNM staging. (F) OS of AKR1B10pos and AKRiB10neg CRC patients in subgroups demarcated by tumor location, depth of tumor invasion, lymph node metastasis, degree of differentiation and TNM staging. (GI) OS of (G) AKR1B10pos and AKRiB10neg CRC patients with TNM staging I-II (H) and III-IV (I). CRC, colorectal cancer. OS, overall survival. ns, no significant difference. ** P < 0.01, *** P < 0.001.