Research Paper Volume 12, Issue 13 pp 13059—13075

Figure 4. AKR1B10 knockdown suppresses CRC tumor growth in vivo. (A–B) Total body weight (A) and tumor volume (B) of the mice during the experiment. (C) Representative pictures of subcutaneous tumors harvested from NC and AKR1B10-KD group. (D) The weights of tumor masses. (E) Net body weight after subtracting the respective tumor weights. (F–G) Relative AKR1B10 (F) and FGF1 (G) mRNA levels in the tumors and their (H) correlation. (I) Stratification of mice into cluster 1 (grey) and cluster 2 (blue) according to body weight, tumor volume, tumor weight and AKR1B10 and FGF1 mRNA levels. (J) Percentage of NC and AKR1B10-KD mice in each cluster. Data are presented as mean ± SD. CRC, colorectal cancer. NC, negative control; KD, AKR1B10-shRNA. *P < 0.05, **P < 0.01, ***P < 0.001.