Research Paper Volume 12, Issue 12 pp 12187—12205

Identification of immunological subtypes of hepatocellular carcinoma with expression profiling of immune-modulating genes

class="figure-viewer-img"

Figure 5.

Survival curves of HCC patients stratified by combined CD8 expression and B7-H3 or CD47 expression in TCGA-LIHC cohort. (A) Overall survival curves of HCC patients stratified by the combined expressions of B7-H3 (CD276) and CD8: the survival of patients with B7-H3low/CD8high is significantly better than that of those with B7-H3high/CD8high (P = 0.004), B7-H3high/CD8low (P = 0.001) or B7-H3low/CD8low (P = 0.012) and no significance between other groups. (B) Survival curves of HCC patients stratified by the combined expressions of CD47 and CD8: the survival of patients with CD47high/CD8low is significantly worse than that of those with CD47low/CD8high (P = 0.008) or CD47low/CD8low (P = 0.045), and no significance between other groups (log rank test). H represents high and L represents low respectively.