Research Paper Volume 12, Issue 17 pp 16775—16802

Identification of cardiovascular health gene variants related to longevity in a Chinese population

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Figure 2. Stratification analysis of metabolic phenotype of TFPI rs7586970 and ADAMTS7 rs3825807. (A) Correlation analysis of allele frequency of TFPI rs7586970 with metabolic phenotype. The frequency of the rs7586970 T is specifically correlated with the metabolic level of lipids (-) +FBG (-) +BMI (+) in centenarians. The allele frequency of rs7586970 T was significantly increased in the centenarians group. (B) Correlation analysis of allele frequency of ADAMTS7 rs3825807 with metabolic phenotype. The frequency of the rs3825807 A is specifically correlated with the metabolic level of lipids (-) +FBG (-) +BMI (-) in centenarians. (C) Correlation analysis of genotype frequency of TFPI rs7586970 with metabolic phenotype. The rs7586970 recessive model (TT/TC+CC) showed a specific correlation with lipids (-) +FBG (-) +BMI (+) in centenarians.