Research Paper Volume 12, Issue 12 pp 12305—12323

Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis

Figure 7. BMP3 regulates the proinflammatory response and migration of FLS and may be associated with the TGF-β1/Smad signaling pathway. (A) The protein levels of p-Smad2 in RA FLS transfected with BMP3 siRNA were analyzed using western blot. (B) The protein levels of p-Smad2 in RA FLS transfected with BMP3-PEX were analyzed using western blot. (C) The protein levels of p-Smad2 in AIA FLS transfected with BMP3-RNAi were analyzed using western blot. (D) The protein levels of p-Smad2 in AIA FLS transfected with BMP3-pcDNA3.1 were analyzed using western blot. All values are expressed as the mean ± SD. *P < 0.05, **P < 0.01 vs normal group. #P < 0.05, ##P < 0.01 vs model group.