Research Paper Volume 12, Issue 14 pp 14189—14204

Co-exposure to multi-walled carbon nanotube and lead ions aggravates hepatotoxicity of nonalcoholic fatty liver via inhibiting AMPK/PPARγ pathway

Figure 4. MWCNTs and PbAc exposure significantly aggravated the nonalcoholic steatohepatitis phenotype in NAFLD mice. (A, B) Histological morphology changes in livers of the control and NAFLD mice exposed to the low dose of PbAc, MWCNTs or MWCNTs + PbAc administration. (C, D) The score of liver damage in the control and NAFLD mice upon the low dose of PbAc, MWCNTs or MWCNTs + PbAc administration (*P<0.05 and **P<0.01, compared to saline water (control) or PbAc).