Research Paper Volume 12, Issue 14 pp 14219—14231

Decreased lncRNA, TINCR, promotes growth of colorectal carcinoma through upregulating microRNA-31

Figure 2. TINCR and miR-31 levels inversely correlate in CRC tissues and cell lines. To explore the potential functions of TINCR in the development of CRC, its expression pattern was investigated in 77 pairs of CRC tissues and peritumoral tissues (PTT). (A, B) RT-qPCR for TINCR (A) and miR-31 (B) in CRC tissues, compared to PTT. (C) Correlation test for TINCR and miR-31 in all 77 cases, which showed a significant inverse correlation (r=-0.3; p<0.0001). (D, E) RT-qPCR for TINCR (D) and miR-31 (E) in human CRC cell lines, including HCT116, SW480, SW620, T84, HT15, LS174T, SNU-C1, Caco-2, LoVo and RKO. (F) Correlation test for TINCR and miR-31 in all examined CRC cell lines, which showed a significant correlation (r=-0.82, p<0.01). Five repeats were done for cell lines.