Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome

Raneem Habib; Ryong Kim; Heidemarie Neitzel; Ilja Demuth; Krystyna Chrzanowska; Eva Seemanova; Renaldo Faber; Martin Digweed; Reinhard Voss; Kathrin Jäger; Karl Sperling; Michael Walter

doi:doi:10.18632/aging.103453

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Research Paper Volume 12, Issue 12 pp 12342—12375

Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome

Figure 3. (A) Total telomere length (TL) analysed by Q-FISH. TL of six NBS lymphoblastoid cell lines and two control lines (06P0131 and 96P0125) was analyzed by Q-FISH. The boxplot presents the median, the minimum and the maximum T/C values. (B) Individual TLs of the NBS line 94P0307 and the control line 06P0131 (red arrows in Figure 3A) analyzed by Q-FISH of 15 metaphases. The boxplot presents the median, the minimum and maximum T/C values. Note the huge variability in TL of the short arm of one chromosome 19 (19p). Original after thesis Raneem Habib [28].