Research Paper Volume 12, Issue 14 pp 14341—14354

LKB1 inactivation leads to centromere defects and genome instability via p53-dependent upregulation of survivin

Figure 2. LKB1 deletion leads to genome instability. (A) Alpha-tubulin staining of proliferating LKB1-WT and LKB1-null cells. (B) DAPI staining showing increased multinucleation in LKB1-null cells. (C) DAPI staining showing increased micronucleation in LKB1-null cells. (D) Quantification of mitotic index in LKB1-WT and LKB1-null cells.