Characterization of aberrant pathways activation and immune microenviroment of BK virus associated nephropathy

Yongguang Liu; Song Zhou; Jianmin Hu; Wentao Xu; Ding Liu; Jun Liao; Guorong Liao; Zefeng Guo; Yuzhu Li; Siqiang Yang; Shichao Li; Hua Chen; Ying Guo; Ming Li; Lipei Fan; Liuyang Li; Anqi Lin; Ming Zhao

doi:doi:10.18632/aging.103486

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Research Paper Volume 12, Issue 14 pp 14434—14451

Characterization of aberrant pathways activation and immune microenviroment of BK virus associated nephropathy

Figure 4. BKVN was associated with increased expression of immune-related genes. (A) The expression of CYT-related genes in the PB (STA and BKV), TKB1 (STA and BKVN) and TKB2 (STA and BKVN) datasets. (B) The expression of APP-related genes in the PB (STA and BKV), TKB1 (STA and BKVN) and TKB2 (STA and BKVN) datasets. (C) The expression of proinflammatory-related genes in the PB (STA and BKV), TKB1 (STA and BKVN) and TKB2 (STA and BKVN) datasets. The thick line represents the median value. The bottom and top of the boxes indicate the 25^th and 75^th percentiles (interquartile range). The whiskers encompass 1.5 times the interquartile range. *, P< 0.05; **, P< 0.01; ***, P< 0.001; and ****, P<0.0001; Mann-Whitney U test.