Research Paper Volume 12, Issue 14 pp 14528—14541

Plasma sex hormone-binding globulin predicts neurodegeneration and clinical progression in prodromal Alzheimer's disease

Figure 1. Relationships of plasma SHBG with CSF SHBG and CSF Aβ42. Plasma and CSF levels of SHBG were highly correlated (A). Higher levels of plasma SHBG were associated with lower levels of CSF Aβ42 after adjusting for age, gender, education, APOE4 status, and MMSE at baseline (B); Higher levels of plasma SHBG were associated with faster decline of CSF Aβ42 after adjusting for age, gender, education, APOE4 status, and diagnosis at baseline (C).