Research Paper Volume 12, Issue 14 pp 14019—14036

Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes

Figure 2. Oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) results during pregnancy (16.5 days), after delivery, and at 12 months of age. OGTT curves for the three groups of mice and comparison of areas under the curve (AUC) during pregnancy (A), after delivery (B), and at 12 months of age (C). ITT curves for the three groups of mice and comparison of AUC during pregnancy (D), after delivery (E), and at 12 months of age (F). *p-value<0.05 versus HFD+vehicle. **p-value<0.01 versus HFD+vehicle.