Research Paper Volume 12, Issue 14 pp 14019—14036

Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes

Figure 5. Principal component analysis of the hypothalamus (A), pituitary gland (B), and ovary (C) collected from maternal mice at 12 months of age. The color legends of experimental mice groups are listed as follows; Red color indicates maternal mice fed with a high-fat diet and metformin during pregnancy (HFD+metformin); Green color indicates maternal mice fed with a low-fat diet during pregnancy (LFD); Blue color indicates maternal mice fed with a high-fat diet during pregnancy (HFD).