Research Paper Volume 12, Issue 14 pp 13991—14018

Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis

Figure 2. Effects of PSE on tolerance of glucose and insulin in HFD-induced diabetic mice. The change on fasting blood glucose (A) and AUC (B) of HFD-induced diabetic mice during OGTT after administering PSE at 10, 80, and 160 mg/kg for 6 weeks. The change on fasting blood glucose (C) and AUC (D) of HFD-induced diabetic mice during ITT after administering PSE at 10, 80, and 160 mg/kg for 6 weeks. The change on serum insulin (E) of HFD-induced diabetic mice after administering PSE at 10, 80, and 160 mg/kg for 6 weeks. Each value was expressed as the mean ± SEM of 10 mice. ## and ### represent significant difference compared to the control group at p < 0.01 and p < 0.001, respectively. *, **, and *** indicate significant difference compared to the DM group at p < 0.05, p < 0.01 and p < 0.001, respectively.