Research Paper Volume 12, Issue 14 pp 14918—14932

RP11-295G20.2 facilitates hepatocellular carcinoma progression via the miR-6884-3p/CCNB1 pathway

Figure 2. RP11-295G20.2 knockdown inhibits the growth, migration and invasion of HCC cells. (A) RT-qPCR results indicated RP11-295G20.2 was successfully silenced in Hep3B and MHCC-97H cells, *P < 0.05. The effect of the RP11-295G20.2 knockdown on cell proliferative capacity was examined using CCK-8 (B) and colony formation assays (C) in Hep3B and MHCC-97H cells, *P < 0.05. (D) The cell apoptosis assay showed that the RP11-295G20.2 knockdown markedly increase apoptosis in Hep3B and MHCC-97H cells, *P < 0.05. Transwell migration (E) and invasion assays (F) were performed to determine the effect of RP11-295G20.2 knockdown on the migration and invasion of Hep3B and MHCC-97H cells, *P < 0.05.