Research Paper Volume 13, Issue 5 pp 7660—7675

Long noncoding RNA NR2F1-AS1 promotes the malignancy of non-small cell lung cancer via sponging microRNA-493-5p and thereby increasing ITGB1 expression

NR2F1-AS1 is highly expressed in NSCLC and is linked with poor NSCLC clinical outcomes. (A) Relative NR2F1-AS1 expression in 73 pairs of NSCLC tissues and matched adjacent normal tissues was evaluated by RT–qPCR. (B) RT–qPCR analysis was employed to assess the expression patterns of NR2F1-AS1 in five NSCLC cell lines and in the normal nontumorigenic bronchial epithelium cell line BEAS-2B. (C) Kaplan–Meier survival curves correlated with the expression level of NR2F1-AS1. High NR2F-AS1 expression relates to shorter overall survival rate NSCLC patients (P = 0.024). *P

Figure 1. NR2F1-AS1 is highly expressed in NSCLC and is linked with poor NSCLC clinical outcomes. (A) Relative NR2F1-AS1 expression in 73 pairs of NSCLC tissues and matched adjacent normal tissues was evaluated by RT–qPCR. (B) RT–qPCR analysis was employed to assess the expression patterns of NR2F1-AS1 in five NSCLC cell lines and in the normal nontumorigenic bronchial epithelium cell line BEAS-2B. (C) Kaplan–Meier survival curves correlated with the expression level of NR2F1-AS1. High NR2F-AS1 expression relates to shorter overall survival rate NSCLC patients (P = 0.024). *P < 0.05 and **P < 0.01.