Research Paper Volume 12, Issue 17 pp 16899—16920

Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes

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Figure 3. Changes in the thymus tissue structure in C57 mice of different ages. Note: (A) shows the thymus from a 2-month-old C57 mouse (20×); (B) shows the thymus from an 18-month-old C57 mouse (20×). HE staining of the thymus in 18-month-old C57 mice: the volume of the thymus was reduced, and the boundary of the cortex and medulla was not clear; most of the thymus tissue had been replaced by adipose tissue.