Research Paper Volume 12, Issue 16 pp 16172—16182
Leptin promotes bone metastasis of breast cancer by activating the SDF-1/CXCR4 axis
Figure 1. Leptin receptor expression was associated with malignancy and bone metastasis in breast cancer patients. (A) IHC staining was employed to examine leptin receptor expression in breast cancer tissues. (B) Frequencies of bone metastasis and non-bone metastasis in patients with low or high leptin receptor expression. (C) Realtime-PCR was used to measure leptin receptor expression in primary breast cancer tissue and bone metastasis tissue. The data are shown as means ± SD, **P<0.01. (D) IHC staining was employed to examine leptin receptor expression in primary breast cancer tissue and bone metastasis tissue.