Research Paper Volume 12, Issue 18 pp 18073—18083

MiR-141-3p ameliorates RIPK1-mediated necroptosis of intestinal epithelial cells in necrotizing enterocolitis

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Figure 2.

MiR-141-3p downregulation participated in LPS-induced Caco-2 cell injury. Cell viability of LPS-treated Caco-2 cells in the presence of miR-141-3p mimics (A) or miR-141-3p inhibitor (B). (C) PI positive staining of LPS-treated Caco-2 cells with miR-141-3p mimics transfection or miR-141-3p inhibitor transfection. The mRNA level of IL-6 (D) and TNF-α (E) in LPS-treated Caco-2 cells with miR-141-3p mimics transfection. The expression of IL-6 (F) and TNF-α (G) in LPS-treated Caco-2 cells with miR-141-3p inhibitor transfection. Scale bar = 20 μm. **p<0.01, ***p<0.001.